MOTS-C 20mg
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino acid mitochondrial-derived peptide (MDP) encoded by a short open reading frame within the mitochondrial 12S rRNA gene (MT-RNR1). Sequence: MRWQEMGYIFYPRKLR. It is supplied as a high-purity lyophilized research reagent for laboratory studies of mitochondrial signalling, AMPK-related energy sensing, and metabolic pathway analysis.
For research and laboratory use only. Not for human consumption.
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- Research Grade - 99% Purity
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Description
MOTS-C is a synthetic 16-residue peptide corresponding to the human mitochondrial-derived peptide first characterised in 2015. Unlike most peptides used in laboratory work, it is encoded in mitochondrial DNA rather than the nuclear genome. The primary sequence is:
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
(MRWQEMGYIFYPRKLR)
In published laboratory models, MOTS-C has been used to study:
- Mitochondrial–nuclear communication
- AMPK (AMP-activated protein kinase) signalling
- Folate-cycle / AICAR-related metabolic pathways
- Glucose handling and insulin-sensitivity assays in cell and animal research systems
- Age- and diet-related metabolic stress models
This material is a research-grade chemical reagent. It is not a medicine, not TGA-approved, and not intended for therapeutic, diagnostic, or veterinary use.
Batch-specific Certificates of Analysis (HPLC and mass spectrometry) are provided where available.
Intended for research and laboratory use only. Not for human consumption.
Specification
- Compound name: MOTS-C (MOTS-c, mitochondrial-derived peptide)
- CAS number: 1627580-64-6
- Sequence (1-letter): MRWQEMGYIFYPRKLR
- Sequence (3-letter): Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Peptide length: 16 amino acids
- Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular weight: 2174.6 g/mol (free peptide)
- Appearance: White to off-white lyophilized powder
- Purity: ≥98% by HPLC (typical research batches ≥99%)
- Identity: Confirmed by mass spectrometry
- Form: Lyophilized powder
- Solubility: Soluble in sterile water or aqueous laboratory buffers
- Storage (lyophilized): −20 °C, dry, protected from light and moisture
- Short-term storage: 2–8 °C
- Source: Synthetic (solid-phase peptide synthesis)
Exact purity, net content, and identity data are listed on the batch CoA.
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