Retatrutide

Retatrutide Vial of Peptide
Retatrutide 20mg Certificate of Analysis (COA)
Retatrutide 15mg Certificate of Analysis (COA)
$150.00 – $190.00Price range: $150.00 through $190.00

For research use only. Not for human consumption.

Retatrutide (LY3437943) is a synthetic 39-amino acid peptide that acts as a triple agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptors. It incorporates structural modifications including α-aminoisobutyric acid (Aib) residues for enhanced stability and a fatty acid moiety for prolonged activity in laboratory models.

This high-purity research-grade triple agonist is intended for in vitro and in vivo studies investigating multi-receptor incretin and glucagon signaling, metabolic regulation, and energy balance.

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  • Research Grade - 99% Purity
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Description

This product is for research and laboratory use only. Not for human consumption, therapeutic, diagnostic, or veterinary purposes.

Retatrutide is a novel synthetic peptide designed as a balanced triple agonist targeting GIP, GLP-1, and glucagon receptors. Built on a modified GIP backbone, it combines the metabolic effects of incretin hormones with glucagon receptor activation. Key modifications include strategic amino acid substitutions (including Aib residues) for proteolytic resistance and lipidation to improve pharmacokinetic properties in experimental settings.

In laboratory research, Retatrutide is used to study:

  • Synergistic effects of triple receptor agonism on metabolism
  • Glucose regulation and insulin sensitivity
  • Energy expenditure and lipid metabolism
  • Comparative pharmacology versus dual agonists (e.g., Tirzepatide)

Retatrutide is supplied as a lyophilized powder with high purity verified by HPLC and mass spectrometry for reproducible research results.

Key Specifications:

  • Compound Name: Retatrutide (LY3437943)
  • CAS Number: 2381089-83-2
  • Molecular Formula: C₂₂₃H₃₄₃N₄₆O₆₈ (approximate)
  • Molecular Weight: ~4,817 g/mol (average)
  • Peptide Length: 39 amino acids
  • Appearance: White to off-white lyophilized powder
  • Purity: ≥98% (HPLC), typical batches ≥99%
  • Solubility: Soluble in water or DMSO for laboratory use
  • Storage: Lyophilized: -20°C. Reconstituted: 2–8°C (short term)
  • Source: Synthetic (solid-phase peptide synthesis)
  • Testing: HPLC, Mass Spectrometry (identity & purity)

Research Applications Retatrutide is a valuable tool for researchers studying multi-pathway metabolic regulation. It is commonly used in laboratory models to investigate the combined effects of GIP, GLP-1, and glucagon receptor activation on energy homeostasis, body composition, and metabolic disease mechanisms.

Storage & Handling Lyophilized Powder (Recommended long-term storage): Store at -20°C in a laboratory freezer in its original sealed vial. Under these conditions, Retatrutide maintains stability for 12–24 months or longer. Protect from moisture and light. Short-term storage at 2–8°C (refrigerator) is acceptable for up to 3–6 months.

Reconstituted Solution: Reconstitute only the amount needed for immediate experiments using sterile water or appropriate laboratory buffer. Store reconstituted Retatrutide at 2–8°C and use within 30 days for best results. For longer storage, aliquot into single-use portions and freeze at -20°C. Avoid repeated freeze-thaw cycles, as they may degrade peptide integrity.

Quality Assurance

  • High-purity research-grade material
  • Batch-specific CoA with HPLC and MS data

Legal & Compliance This product is sold strictly for research and laboratory use only. It is not a pharmaceutical product and has not been approved by the Therapeutic Goods Administration (TGA) or any other regulatory authority. The buyer assumes full responsibility for legal compliance and proper laboratory use.

Additional information

Size

15mg, 20mg
Research Focus

Glucose Regulation, Incretin Receptor Studies, Insulin Signaling, Metabolic Research, Triple Agonist Research, Weight Regulation Research